Hesperetin is a natural flavonoid compound that is widely found in fruits, flowers, foods and other plant-derived substances. Its main source is Chemicalbook, which is hydrolyzed from hesperidin (Hesperidin). It has biological and pharmacological activities and is widely used in many fields such as organic chemistry, medicine, agronomy, and food.
① Hesperetin low density 98.0% HPLC
② Hesperetin high density 98.0% HPLC
(1)Antioxidant effect: Hesperetin can avoid cellulose caused by peroxidation reaction by removing peroxynitrite ions.
(2) Anti-inflammatory effect: Hesperetin can inhibit the mediating effect of inflammatory mediators, thereby promoting the pivot regulatory response. Compared with hesperetin, hesperetin has a stronger anti-inflammatory effect. After hesperetin C7 is connected to rue sugar, its anti-inflammatory activity is affected.
(3) Blood-lipid-lowering effect: Hesperetin can inhibit the action of cholesterol-generating enzymes and esterification enzymes, thereby achieving the effect of lowering blood-lipidemia.
(4) Cardiovascular protective effect: Hesperetin has the effect of reducing blood lipids and vascular permeability, and can prevent thrombosis. Hesperetin can also protect endothelial cells from hypoxia in Chemicalbook tissue by stimulating certain mitochondrial enzymes such as succinate dehydrogenase, preventing coagulation caused by endothelial cell necrosis and inducing thrombosis. In addition, hesperetin promotes antiplatelet coagulation activity by inhibiting the
phosphorylation of PLCγ2 and its downstream signaling, which can prevent the formation of thrombus and benefit the cardiovascular system.
(5)Anti-tumor effect: Hesperetin has antioxidant effects, which can avoid canceration caused by genetic changes caused by these factors. Promote the efflux of P-glycoprotein-mediated drugs from tumor cells. Flavonoids (hesperetin, etc.) can change the permeability of the blood-brain barrier to vincristine, and are also related to its concentration. Low concentrations of flavonoids can reduce the uptake of vincristine by brain capillary endothelial cells; conversely, high concentrations can promote it.
Analysis Items | Specifications | Methods |
Identifications | ||
| IR spectrum is concordant with spectrum of Hesperetin RS. | |
| Retention time of the sample matches with the standard in HPLC purity test.. | |
Physical Tests | ||
Appearance | White to light yellow | Visual |
Taste & smell | Characteristic | Organoleptic |
Bulk density | 0.3-0.6g/mL | 0.48g/mL |
Water | ≤2.00% | 1.31% |
Residue on Ignition | ≤1.00% | USP43 |
Active Ingredients Tests | ||
Hesperetin | ≥98.00% | HPLC |
Chemical Tests | ||
Heavy Metals | ≤10.00ppm | USP43 |
Pb | ≤1.00ppm | USP43 |
As | ≤2.00ppm | USP43 |
Cd | ≤0.10ppm | USP43 |
Hg | ≤1.00ppm | USP43 |
Residue of Iron | ≤10.00ppm | USP43 |
Residue of Chloride | ≤200ppm | USP43 |
Residue of Sulfate | ≤300ppm | USP43 |
Microbiological Tests | ||
Total Bacterial Counts | ≤1,000cfu/g | USP43 |
Yeasts and Molds | ≤100cfu/g | USP43 |
E. Coli | Negative in 1g | USP43 |
Salmonella | Negative in 10g | USP43 |
Staphylococcus aureus | Negative in 1g | USP43 |
* Conclusion: Conform to above specifications. | ||
* Statements : Irradiated free, GMO free, Additives free. | ||
* Packaging: 1/5kg per bag or 25kg per fiber drum. | ||
* Storage Condition: Preserve in well-closed, tight containers with temperature below 25℃. | ||
* Shelf Life: 3 years when properly stored. |
Healthway is not only a raw material supplier, but also can provide one-stop service for customers, providing finished products service for Amazon and online store customers. We can do product subcontracting, filling capsules and tablets private label to meet all your needs.
Market situation:
Hesperetin is used in health care drugs and health products. For example, Amway’s series of products are added with hesperetin. The best-selling health product Vitality 50 in the United States, its main active ingredient is also hesperetin.
As an additive in some Chemicalbook cosmetics, such as CLARINS, many night creams contain hesperetin.
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