The second part
The relationship between NAD+ and disease:
Lesions caused by abnormal NAD+ metabolism
01.NAD+ and infection
It is currently known that infection by several viruses will cause a significant decrease in n repair damage by activating PARPs, thereby clearing viruses and fighting infection.
02.NAD+ and aging
Research shows that the body’s NAD+ levels decline with age. Decreased NAD+ levels are one of the main factors in biological dysfunction and will accelerate aging. Experiments have proven that supplementing NAD+ can delay aging.
03. Decreased NAD+ causes mitochondrial dysfunction
Mitochondrial dysfunction is one of the hallmarks of aging, and NAD+ deficiency is an important cause of this condition. Restoring NAD+ levels through NAD+ supplements and other methods can significantly improve mitochondrial function.
04.NAD+ and oxidative stress
Maintaining a normal NADH/NADPH ratio can significantly alleviate cellular oxidative stress, and NAD+ is the core regulator of this ratio.
05.NAD+ and circadian rhythm
Supplementing NAD+ and increasing the body’s NAD+ content are necessary factors for cells to maintain circadian rhythm.
06.NAD+ and metabolic diseases
For people with type 2 diabetes, obesity and non-alcoholic fatty liver disease, the NAD+ levels in their tissue cells will decrease significantly. NAD+ supplementation can increase NAD+ levels, thereby improving the conditions of these three metabolic diseases.
07.NAD+ and kidney failure
In experimental mice with renal failure, it was found that NAD+ was greatly depleted, and the NAD+ synthesis ability in the kidneys also decreased, resulting in a decrease in NAD+ levels. In addition, NAD+ also plays an important role in a variety of common neurodegenerative diseases and cardiovascular diseases.
the third part
Help replenish NAD+ with NMN
NAD+ is a coenzyme for hundreds of important metabolic enzymes in cells, and participates in many important cellular processes as a signaling molecule, closely related to energy metabolism, glycolysis, DNA replication and other activities. And many of the above situations are inseparable from the participation of NAD+, so supplementing NAD+ is very critical.
NAD+ precursor: NMN
We can increase human NAD+ levels by taking NMN orally. NMN is the precursor for the synthesis of NAD+ (coenzyme I) in the human body. A number of animal experiments have proven that NMN can quickly increase the level of NAD+ in cells and is extremely safe.
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Post time: Dec-26-2023
